RealTalk MS Jon Strum

In past episodes of this podcast, we've discussed disparities in healthcare. We've looked at evidence that shows members of historically underserved communities who are living with MS can face a more severe disease course. We've looked at studies that have shown some members of these racial and ethnic minority groups don't do as well on disease-modifying therapies, and their MS progresses more quickly.
It's often been speculated that the reason behind these disparities is based on genetics -- that members of minority communities who are living with MS are genetically predisposed to experiencing a more severe disease course. 

My guest in this episode is Dr. Annette Langer-Gould, and Dr. Langer-Gould comes armed with evidence that points to a completely different set of answers for the cause of racial and ethnic disparities in MS disease severity and progression.
We're also sharing registration details for the National MS Society's MS Activist Rally on April 25th!
We'll tell you about an inverse vaccine that prevents the mouse model of MS (and we'll explain what an inverse vaccine is!)
You'll find out where you can find the just-released video progress report from the International Progressive MS Alliance.
We'll explain just-published results from an analysis that shows why anti-diabetic and weight-loss drugs like Ozempic, Jardiance, and Trulicity may be repurposed as MS therapies.
And we're sharing study results with both good news and not so great news when it comes to being diagnosed and treated for MS in a timely manner.
We have a lot to talk about! Are you ready for RealTalk MS??!

This Week: We're exploring the reason that members of underserved minority populations who are living with MS often experience a more severe disease course  :22
The MS Activist Rally is happening on 4/25!  1:28
An inverse vaccine prevents the mouse model of MS  3:49
The International Progressive MS Alliance has released their 2024 progress report  6:13
Can weight-loss drugs be repurposed as MS therapies?  7:33
A study shows that getting diagnosed and treated for MS is dependent upon your country's healthcare system  10:26
Dr. Annette Langer-Gould has a sobering answer as to why some members of minority communities who are living with MS experience a more severe disease course  14:48
Share this episode  31:31
Have you downloaded the free RealTalk MS app?  31:51

SHARE THIS EPISODE OF REALTALK MS
Just copy this link & paste it into your text or email: https://realtalkms.com/346
ADD YOUR VOICE TO THE CONVERSATION
I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts!
Email: jon@realtalkms.com
Phone: (310) 526-2283
And don't forget to join us in the RealTalk MS Facebook group!

LINKS
If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com
REGISTER for the MS Activist Rally
https://events.zoom.us/ev/Ame2jWSuHmriG94cyQmlWHr45mgnzxkDv8oMZRGsrS3ZxiSj5rro~Anqb3dHg3ewiz4KNHn2Ena4bgli_WXlza_zcygZN3GinnleB6rO15OCzGQ

VIDEO: International Progressive MS Alliance 2024 Progress Report
https://www.youtube.com/watch?v=4ojRaLp_J1w

STUDY: Exploring the Association Between Weight Loss-Inducing Medications and Multiple Sclerosis: Insights from the FDA Adverse Event Reporting System Database
https://journals.sagepub.com/doi/10.1177/17562864241241383

STUDY: Disease-Modifying Therapy Initiation Patterns in Multiple Sclerosis in Three Large Populations
https://journals.sagepub.com/doi/10.1177/17562864241233044
Join the RealTalk MS Facebook Group
https://facebook.com/groups/realtalkms
Download the RealTalk MS App for iOS Devices
https://itunes.a

MS affects women almost 3 times more frequently than it affects men, which makes understanding how MS may impact other women's health issues a priority.
Dr. Rhonda Voskuhl and Dr. Anna Shah join me as we take a deep dive into both the research and clinical side of how MS affects women's health and how those other health issues may affect MS.

Dr. Shah is an Associate Professor of Neurology and Associate Clinic Director of Outpatient Neurology at the University of Colorado School of Medicine.
Dr. Voskuhl is the Director of the UCLA Multiple Sclerosis Program, she holds the Jack H. Skirball Chair in MS, she's a Professor in the UCLA Department of Neurology, and Dr. Voskuhl also serves as Faculty Neurologist of the UCLA Comprehensive Menopause Care Program.
We have a lot to talk about! Are you ready for RealTalk MS??!

This Week: We're taking a deep dive into women's health and MS  :22
Dr. Rhonda Voskuhl named the recipient of the 2024 John Dystel Prize for Multiple Sclerosis Research  :52
Dr. Rhonda Voskuhl discusses her research looking at why MS affects men and women differently   2:32
Dr. Anna Shah discusses how MS can affect women's health issues and how those health issues can affect MS  13:21
Share this episode  32:40
Have you downloaded the free RealTalk MS app?  33:00

SHARE THIS EPISODE OF REALTALK MS
Just copy this link & paste it into your text or email: https://realtalkms.com/345
ADD YOUR VOICE TO THE CONVERSATION
I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts!
Email: jon@realtalkms.com
Phone: (310) 526-2283
And don't forget to join us in the RealTalk MS Facebook group!

LINKS
If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com
Join the RealTalk MS Facebook Group
https://facebook.com/groups/realtalkms
Download the RealTalk MS App for iOS Devices
https://itunes.apple.com/us/app/realtalk-ms/id1436917200
Download the RealTalk MS App for Android Devices
https://play.google.com/store/apps/details?id=tv.wizzard.android.realtalk
Give RealTalk MS a rating and review
http://www.realtalkms.com/review

Follow RealTalk MS on Twitter, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com.
RealTalk MS Episode 345
Guests: Dr. Rhonda Voskuhl and Dr. Anna Shah
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If you're a regular listener, you've probably heard me say that the pace of scientific discovery is moving faster than ever before. Or you may have heard the National MS Society remind us that we've seen as many advances in MS research in the past 5 years as we have in the previous 70 years. Have you ever wondered why?
A major driver of this acceleration of discovery is the technology that allows scientists to analyze massive amounts of information looking for relationships or identifying characteristics that, without this technology, would be impossible to see. 
This category of tech is commonly referred to as big data. And we're closer than we've ever been to understanding the biological complexities of multiple sclerosis because we've learned to harness the computing power that allows scientists to discover those very small needles among those very large haystacks.

My guest in this episode is Professor Sergio Baranzini. Professor Baranzini is this year's recipient of the Barancik Prize for Innovation in MS Research and he's someone who has successfully leveraged big data to drive big, game-changing discoveries in multiple sclerosis.
We'll also share some good news about MS research funding from the federal government. 
We'll review newly published results from a study that has identified 3 subtypes of MS, each with a different disease trajectory.
We'll share evidence from a study that focused on whether people over the age of 50 with nonactive MS should discontinue their disease-modifying therapy.
And we'll tell you about the Canadian regulatory approval of a software-based medical device that can monitor MS disease activity by tracking eye movement -- all from an iPad that people with MS can use at home.
We have a lot to talk about! Are you ready for RealTalk MS??!

This Week: We're saluting Professor Sergio Baranzini, this year's winner of the Barancik Prize  :22
Congress provides $20 million in FY2024 funding for the MS Research Program  1:57
A German research team has identified 3 subtypes of MS based on their unique immune cell signature found in a blood sample  4:10
A French research team focused their study on whether people over the age of 50 with nonactive MS should discontinue their DMT. Here's what they discovered  8:58
Health Canada has approved ETNA-MS. A software-based medical device that can monitor MS disease activity by tracking eye movement  12:48
Professor Sergio Baranzini discusses how big data has fundamentally changed scientific research, and how he's using it to find cures for MS  16:44
Share this episode  32:03
Have you downloaded the free RealTalk MS app?  32:24

SHARE THIS EPISODE OF REALTALK MS
Just copy this link & paste it into your text or email: https://realtalkms.com/344
ADD YOUR VOICE TO THE CONVERSATION
I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts!
Email: jon@realtalkms.com
Phone: (310) 526-2283
And don't forget to join us in the RealTalk MS Facebook group!

LINKS
If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com
REGISTER for the MS Activist Rally
https://events.zoom.us/ev/Ame2jWSuHmriG94cyQmlWHr45mgnzxkDv8oMZRGsrS3ZxiSj5rro~Anqb3dHg3ewiz4KNHn2Ena4bgli_WXlza_zcygZN3GinnleB6rO15OCzGQ

STUDY: Multiple Sclerosis Endophenotypes Identified by High-Dimensional Blood Signatures are Associated with Distinct Disease Trajectories
https://science.org/doi/10.1126/scitranslmed.ade8560

STUDY: High-Efficacy Therapy Discontinuation vs Continuation in Patients 50 Years and Older with Nonactive MS
https://jamanetwork.com/journals/jamaneurology/article-abstract/2816799

Joi

March 28th is Progressive MS Day, a day that offers an opportunity for people affected by MS, patient advocates, healthcare providers, governments, and industry to share stories online and show their support for people living with progressive forms of MS. 
My wife, Jeanne, lived with progressive MS for 23 years, so this day holds a special significance for me. Joining me to talk about what Progressive MS Day is all about is my friend, Kevin Reid. Kevin was diagnosed with MS in 2002 and, for the past 10 years, he's been on a mission to crush MS.

As MS Awareness Month draws to a close, we're sharing a series of short videos featuring conversations I had with MS experts at the ECTRIMS congress. What makes this video series unique is that iConquer MS invited people living with MS to watch these videos. Then, I interviewed them to get their perspective on the topics the experts were discussing. It's the first time you'll not only hear from the experts, but you'll also get the thoughts and reactions of people who are living with MS.
We'll tell you about the neurostimulator that was just designated as a Breakthrough Device for promoting myelin repair.
We'll share the details of a newly announced Phase 2 clinical trial for a T-cell therapy for MS.
You'll hear about the study that identified a biomarker that reliably predicted the likelihood of future disease activity in people with MS.
And we'll tell you where you can catch the video replay of the 2024 ACTRIMS Forum Patient-Centered Webinars.
We have a lot to talk about! Are you ready for RealTalk MS??!

This Week: March 28th is Progressive MS Day  :22
Have you seen the series of short videos featuring my conversations with MS experts at ECTRIMS along with the thoughts and reactions from people living with MS?  1:00
Catch the video replay of the 2024 ACTRIMS Forum Patient-Centered Webinars  1:57
FDA designates neurostimulator as a breakthrough device for promoting myelin repair in people living with relapsing-remitting MS  2:46
Biotech company PolTREG announces Phase 2 clinical trials to test their Tregs treatment for MS  5:28
Study shows neurofilament light chain levels can reliably predict future disease activity  7:10
Kevin Reid discusses the importance of Progressive MS Day and gives us a preview of CRUSH MS  10:35
Share this episode  28:09
Have you downloaded the free RealTalk MS app?  28:29

SHARE THIS EPISODE OF REALTALK MS
Just copy this link & paste it into your text or email: https://realtalkms.com/343
ADD YOUR VOICE TO THE CONVERSATION
I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts!
Email: jon@realtalkms.com
Phone: (310) 526-2283
And don't forget to join us in the RealTalk MS Facebook group!

LINKS
If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com
VIDEO: Dr. Jiwon Oh shares encouraging results from an extension study of Tolebrutinib, an investigational disease-modifying therapy. Then, two people living with MS share their thoughts about clinical trials and a precision medicine approach to treating MS
https://youtu.be/eWoZLF4bZmo
VIDEO: Dr. Anthony Feinstein discusses the outcome of the CogEx study, Then, two people living with MS share their thoughts about the impact of this study
https://www.youtube.com/watch?v=UtGtCnNkYOY

VIDEO: Dr. Annette Langer-Gould discusses the impact of other health conditions on people living with MS. Then, two people living with MS share their thoughts and experiences of  managing their MS along with additional health conditions
https://www.youtube.com/watch?v=J83jlqMbsZo
VIDEO: Dr. Daniel Ontaneda discusses how ar

We often discuss the results of MS research studies on this podcast. In order to get to those results, people living with MS have to step up and volunteer to participate. This week, you'll meet Chiquita Shepard-Knight and Earl Sneed, two participants in the TEAAMS study.

Chiquita and Earl will discuss how they discovered the TEAAMS study, what motivated them to get involved, what their experience as study participants was like, and what the results of the study were for them.
We'll also take you to Capitol Hill as we share conversations that we had during Hill Day at the National MS Society's Public Policy Conference. 
It's MS Awareness Month, and we're sharing new videos that feature interviews with leading MS experts along with the thoughts and reactions of people living with MS.
And we'll tell you where you can catch the video replay of the International Progressive MS Alliance's webcast on emerging treatments for progressive MS.
We have a lot to talk about! Are you ready for RealTalk MS??!

Tomorrow! The ACTRIMS Post-Forum Patient-Centered Webinar  :22
This Week: The patient perspective on participating in an MS research study  1:38
Live! From the Natinal MS Society's Public Policy Conference  2:28
People with MS weign in on the impact of several ECTRIMS presentations  10:17
Catch the video replay of the International Progressive MS Alliance webcast  11:35
Chiquita Shepard-Knight and Earl Sneed discuss their experience participating in the TEAAMS study   12:11
Share this episode  27:18
Have you downloaded the free RealTalk MS app?  27:38

SHARE THIS EPISODE OF REALTALK MS
Just copy this link & paste it into your text or email: https://realtalkms.com/342
ADD YOUR VOICE TO THE CONVERSATION
I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts!
Email: jon@realtalkms.com
Phone: (310) 526-2283
And don't forget to join us in the RealTalk MS Facebook group!

LINKS
If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com
REGISTER: ACTRIMS Post-Forum Patient-Centered Webinar
https://fs2.formsite.com/1FItkk/tgx8tu3xg0/index

VIDEO: Dr. Jiwon Oh shares encouraging results from an extension study of Tolebrutinib, an investigational disease-modifying therapy. Then, two people living with MS share their thoughts about clinical trials and a precision medicine approach to treating MS
https://youtu.be/eWoZLF4bZmo
VIDEO: Dr. Anthony Feinstein discusses the outcome of the CogEx study, Then, two people living with MS share their thoughts about the impact of this study
https://www.youtube.com/watch?v=UtGtCnNkYOY

VIDEO: Dr. Annette Langer-Gould discusses the impact of other health conditions on people living with MS. Then, two people living with MS share their thoughts and experiences of  managing their MS along with additional health conditions
https://www.youtube.com/watch?v=J83jlqMbsZo
VIDEO: Dr. Daniel Ontaneda discusses how artificial intelligence will impact MS treatment. Then, two people living with MS share their thoughts on the potential impact of AI on MS treatment and the future patient experience
https://www.youtube.com/watch?v=_fRLW69Xc1A

VIDEO: Dr. Robert Motl discusses the benefits of exercise for people living with MS. Then, two people living with MS share their thoughts on how exercise has impacted their MS journey
https://www.youtube.com/watch?v=oZDdp8JumFg
VIDEO: International Progressive MS Alliance Webcast Replay: Emerging Treatments for Progressive MS
https://www.youtube.com/watch?v=W4hxtl38MBQ
The TEAAMS Study
https://projectteaams.ahs.uic.edu
Join the RealTalk MS Facebook Group
https://faceb

Vision impairment is a key symptom of multiple sclerosis. In fact, many people experience optic neuritis as the very first sign of MS. People living with MS may also experience other vision-related issues including internuclear ophthalmoplegia, diplopia, nystagmus, oscillopsia, and reading fatigue. 

Dr. Shiv Saidha joins me as we take a deep dive into strategies for navigating MS-related vision issues while managing and optimizing your vision. Dr. Saidha is a professor of neurology in the Division of Neuroimmunology and Neurological Infections at Johns Hopkins Medicine.
We have a lot to talk about! Are you ready for RealTalk MS??!

This Week: We're taking a deep dive into managing MS-related vision issues  :22
Doctor Shiv Saidha discusses how to best manage MS-related vision issues  1:17
Share this episode  29:44
Have you downloaded the free RealTalk MS app?  30:05

SHARE THIS EPISODE OF REALTALK MS
Just copy this link & paste it into your text or email: https://realtalkms.com/341
ADD YOUR VOICE TO THE CONVERSATION
I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts!
Email: jon@realtalkms.com
Phone: (310) 526-2283
And don't forget to join us in the RealTalk MS Facebook group!

LINKS
If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com
Join the RealTalk MS Facebook Group
https://facebook.com/groups/realtalkms
Download the RealTalk MS App for iOS Devices
https://itunes.apple.com/us/app/realtalk-ms/id1436917200
Download the RealTalk MS App for Android Devices
https://play.google.com/store/apps/details?id=tv.wizzard.android.realtalk
Give RealTalk MS a rating and review
http://www.realtalkms.com/review

Follow RealTalk MS on Twitter, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com.
RealTalk MS Episode 341
Guest: Dr. Shiv Saidha
Privacy Policy